报告题目：Stochastic Optimal Control of HIV-1 CNS Dynamics with Linear Costs: Optimizing cART and Reducing Latent Reservoirs

报告人：王玮明教授淮阴师范学院单位

报告时间：2026年9月17日星期四下午3：40-4：20

报告地点：正新楼313室

校内联系人：刘素莉 [email protected]

报告摘要：

  HIV-1 remains a formidable global health challenge, as complete viral eradication is still unattainable despite considerable advances in combination antiretroviral therapy(cART) . To address this, we develop a stochastic differential equation (SDE) model that incorporates environmental noise into a classical HIV-1infection dynamics framework, establishing two key advances. Mathematically, we derive the stochastic basic reproduction number Rs and establish the corresponding threshold dynamics: when Rs < 1 (under mild conditions), the infection is almost surely cleared, whereas for Rs > 1, the virus persists stochastically, following an ergodic stationary distribution. Epidemiologically, we demonstrate that environmental noise profoundly influences HIV-1 dynamics and reaffirm the central role of cART. Using optimal control theory, we evaluate three intervention strategies: Strategy 1 (cART enhancement), Strategy 2(immune modulation), and Strategy 3 (a combined cART-immune approach) . Both statistical indicators and dynamical outcomes confirm that Strategy 3 provides a clear advantage in promoting rapid viral suppression by integrating cART enhancement with immune modulation. Moreover, we observe that this combined intervention remains highly effective even under stringent cost constraints, and further reductions in intervention cost could improve its cost-efficiency. These results provide not only a novel theoretical framework for understanding HIV-1 infection dynamics, but also actionable clinical insights for optimizing treatment protocols, underscoring the critical importance of cost considerations in HIV-1 management.

报告人简介：

  王玮明博士，二级教授，淮阴师范学院“翔宇学者”，江苏省十四五“数学”重点学科带头人；江苏省高校科技创新团队带头人；淮安市传染病防控及预警重点实验室主任。入选浙江省“新世纪151人才工程”第二层次，担任浙江省十二五“应用数学”重点学科带头人。近十年来专注于传染病防控的建模分析及预警研究，得到了国家自然科学基金的连续资助，主持面上项目4项。入选爱思唯尔2020--2024“中国高被引学者”、科睿唯安2021-2022 “全球高被引科学家”以及斯坦福大学2022-2024“全球前2%科学家”等榜单。任中科院二区SCI杂志Advances in Continuous and Discrete Models和International Journal of Biomathematics编委。